In this research, we analyze the meaning of science discourse in the podcast Café da Manhã during the Covid-19 pandemic in Brazil, in a context of epistemic crisis in the journalistic and scientific fields. By applying French Discourse Analysis in episodes that dealt with vaccines, we identified three main discourse units: the government was negligent and negligent; vaccination is governed by the market economy; the benefits of vaccines outweigh their risks. From these nuclei of meaning, we observe the influence of the sociopolitical climate permeated by misinformation and denial in the contruction of journalistic discourse about the techno-scientific discoveries during the pandemic.