The study describes and analyzes the production of a health communication podcast based on the ‘Health Handbook of Persons Affected by Leprosy’, produced by the Brazilian Ministry of Health, in 2020. In a study that analyzed the perception of users treated at a specialized public outpatient clinic, it was observed that some of them were unable to read and interpret printed text. The perceived difficulties motivated the adaptation of the content and, thus, the Podhans podcast was created. With accessible and relaxed language, the 16 episodes explore useful topics about the daily lives of people with leprosy and the disease, created from listening to users and considering principles of public communication. Available online, it can be used in the Brazilian Unified Health System (SUS) services and by social movements, expanding access to health information and communication about leprosy.